CReSCENT, a scalable and standardized set of novel computational tools and data portal, was launched and is available for use to researchers on any computing platform. This open-source platform allows scientists to perform systemic analysis on their single-cell RNA-seq data by tapping into the large public reference data sets available through the platform. Moreover, through the data-sharing and collaboration-enabling function embedded in the CReSCENT portal, this platform brings together researchers across a broad spectrum of scientific areas and disease types to increase the impact of data generated across research programs.